Figure 4
From: LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis
KRT23 hepatic expression in animal models of liver injury and in LPCs.
(a) Relationship between KRT23 hepatic gene expression and LPS serum levels in patients with AH (n = 39). Correlation between LPS serum levels and ABIC score in patients with AH. (b) Krt23 hepatic gene expression in a mouse model of acute liver injury. Krt23 gene expression in mice treated with LPS (n = 6) compared to control mice (n = 6). (c) Krt23 hepatic gene expression in a mouse model of advanced fibrosis. Krt23 in mice treated CCl4 plus LPS (n = 8) compared to mice treated with CCl4 alone (n = 6). (d) Gene expression of KRT23 and LPCs markers (KRT7 and EPCAM) in a model of liver progenitor cell differentiation from 3 independent experiments.
