Figure 6
From: LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis
KRT23 regulation by HDACs in mice liver progenitor cells and KRT23 effects on collagen synthesis.
(a) Effect of HDAC inhibition by NaB administration on Krt23 gene expression in BAML cells (3 independent experiments). (b) Gene expression of Sirt1, an HDAC, in a BAML cells treated with NaB (3 independent experiments). (c) Correlation between KRT23 hepatic gene expression and COL1A1 hepatic gene expression in patients with AH (n = 39). (d) Effect of HDACs inhibition by NaB administration on Col1a1 gene expression in BAML cells. (e) Silencing of Krt23 by means of siRNA inhibited NaB induced Col1a1 gene expression in BAML cells (3 independent experiments).
