Figure 6
Modulation of PKC or ERK signalling affects the motility of S. mansoni somules.
Somules were incubated in increasing concentrations of (a) GF109203X, (b) PMA, or (c) U0126 and movies captured at 2 h, 24 h, or 48 h. Motility (standard deviation of perimeter) of somules was determined using ImageJ over 10 s at each time point, with mean values (±SEM; n = 30) determined from three independent experiments. *p≤0.05, **p≤ 0.01, and ***p≤ 0.001, when compared to respective control values as follows: GF109203X = media (control); PMA and U0126: 1–30 μM = 0.1% DMSO, 50 μM = 1% DMSO.
