Table 3 Relationship between Polymorphisms of SCL19A1, FPGS, or GGH and the Intracellular MTXPG3-5/1-2 Ratio.

From: Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis

SNP

rs No.

genotype

n

Intracellular MTXPG3-5/1-2 ratio

P value

Mean ± SD

Median [IQR]

SLC19A1

rs1051266

GG

94

0.479 ± 0.356

0.367 [0.250–0.607]

p = 0.475

AG

130

0.556 ± 0.466

0.427 [0.234–0.794]

AA

47

0.445 ± 0.334

0.338 [0.157–0.707]

FPGS

rs10106

AA

130

0.457 ± 0.375

0.345 [0.201–0.567]

p = 0.006

AG

115

0.503 ± 0.394

0.396 [0.235–0.656]

GG

26

0.714 ± 0.465

0.672 [0.364–0.957]

rs1054774

TT

113

0.555 ± 0.404

0.428 [0.264–0.788]

p = 0.008

AT

122

0.463 ± 0.396

0.350 [0.201–0.562]

AA

36

0.417 ± 0.362

0.319 [0.161–0.568]

rs1544105

CC

128

0.454 ± 0.372

0.347 [0.202–0.565]

p = 0.003

CT

120

0.506 ± 0.391

0.396 [0.235–0.700]

TT

23

0.747 ± 0.489

0.634 [0.385–1.030]

GGH

rs719235

CC

216

0.501 ± 0.389

0.385 [0.238–0.652]

p = 0.862

CT

47

0.486 ± 0.378

0.385 [0.184–0.633]

TT

8

0.645 ± 0.702

0.382 [0.205–0.859]

rs1800909

CC

223

0.495 ± 0.397

0.397 [0.220–0.634]

p = 0.882

CT

36

0.524 ± 0.401

0.255 [0.255–0.668]

TT

12

0.444 ± 0.229

0.375 [0.297–0.710]

rs3758149

GG

232

0.498 ± 0.401

0.383 [0.234–0.616]

p = 0.889

GT

27

0.552 ± 0.422

0.381 [0.240–0.869]

TT

12

0.441 ± 0.241

0.385 [0.274–0.697]

rs11545078

TT

233

0.495 ± 0.391

0.376 [0.234–0.634]

p = 0.321

CT

37

0.558 ± 0.437

0.430 [0.232–0.702]

CC

1

0.151

0.151

rs12681874

GG

81

0.452 ± 0.332

0.362 [0.235–0.604]

p = 0.070

AG

134

0.600 ± 0.472

0.442 [0.254–0.812]

AA

60

0.493 ± 0.418

0.345 [0.197–0.687]

  1. n  =  number of patients
  2. p values for comparisons among 3 groups were evaluated by the Kruskal-Wallis test.
  3. SLC19A1: reduced folate carrier 1, FPGS: folylpolyglutamyl synthase, GGH: gamma-glutamyl hydrolase.