Table 3 Relationship between Polymorphisms of SCL19A1, FPGS, or GGH and the Intracellular MTXPG3-5/1-2 Ratio.
SNP | rs No. | genotype | n | Intracellular MTXPG3-5/1-2 ratio | P value | |
---|---|---|---|---|---|---|
Mean ± SD | Median [IQR] | |||||
SLC19A1 | rs1051266 | GG | 94 | 0.479 ± 0.356 | 0.367 [0.250–0.607] | p = 0.475 |
AG | 130 | 0.556 ± 0.466 | 0.427 [0.234–0.794] | |||
AA | 47 | 0.445 ± 0.334 | 0.338 [0.157–0.707] | |||
FPGS | rs10106 | AA | 130 | 0.457 ± 0.375 | 0.345 [0.201–0.567] | p = 0.006 |
AG | 115 | 0.503 ± 0.394 | 0.396 [0.235–0.656] | |||
GG | 26 | 0.714 ± 0.465 | 0.672 [0.364–0.957] | |||
rs1054774 | TT | 113 | 0.555 ± 0.404 | 0.428 [0.264–0.788] | p = 0.008 | |
AT | 122 | 0.463 ± 0.396 | 0.350 [0.201–0.562] | |||
AA | 36 | 0.417 ± 0.362 | 0.319 [0.161–0.568] | |||
rs1544105 | CC | 128 | 0.454 ± 0.372 | 0.347 [0.202–0.565] | p = 0.003 | |
CT | 120 | 0.506 ± 0.391 | 0.396 [0.235–0.700] | |||
TT | 23 | 0.747 ± 0.489 | 0.634 [0.385–1.030] | |||
GGH | rs719235 | CC | 216 | 0.501 ± 0.389 | 0.385 [0.238–0.652] | p = 0.862 |
CT | 47 | 0.486 ± 0.378 | 0.385 [0.184–0.633] | |||
TT | 8 | 0.645 ± 0.702 | 0.382 [0.205–0.859] | |||
rs1800909 | CC | 223 | 0.495 ± 0.397 | 0.397 [0.220–0.634] | p = 0.882 | |
CT | 36 | 0.524 ± 0.401 | 0.255 [0.255–0.668] | |||
TT | 12 | 0.444 ± 0.229 | 0.375 [0.297–0.710] | |||
rs3758149 | GG | 232 | 0.498 ± 0.401 | 0.383 [0.234–0.616] | p = 0.889 | |
GT | 27 | 0.552 ± 0.422 | 0.381 [0.240–0.869] | |||
TT | 12 | 0.441 ± 0.241 | 0.385 [0.274–0.697] | |||
rs11545078 | TT | 233 | 0.495 ± 0.391 | 0.376 [0.234–0.634] | p = 0.321 | |
CT | 37 | 0.558 ± 0.437 | 0.430 [0.232–0.702] | |||
CC | 1 | 0.151 | 0.151 | |||
rs12681874 | GG | 81 | 0.452 ± 0.332 | 0.362 [0.235–0.604] | p = 0.070 | |
AG | 134 | 0.600 ± 0.472 | 0.442 [0.254–0.812] | |||
AA | 60 | 0.493 ± 0.418 | 0.345 [0.197–0.687] |