Table 5 Allele frequency in several genotypes of SLC19A1 FPGS and GGH in our patients with rheumatoid arthritis and in general populations of Japanese and Caucasian.

From: Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis

SNPs

No of rs

genotype

Minor Allele Frequency

P value

Our study

Japanese

Caucasian

SLC19A1

rs1051266

80G > A

0.698/0.302

0.512/0.488

0.438/0.562

p = 0.210

FPGS

rs10106

1994A > G

0.693/0.307

0.727/0.273

0.450/0.550

p < 0.01

rs1054774

11694T > A

0.360/0.640

0.330/0.670

0.342/0.658

p = 0.471

rs1544105

2572C > T

0.717/0.283

0.727/0.273

0.342/0.658

p < 0.01

GGH

rs719235

452C > T

0.892/0.108

0.895/0.105

0.677/0.323

p < 0.01

rs1800909

−401C > T

0.850/0.150

0.727/0.273

0.342/0.658

p = 0.478

rs3758149

−354G > T

0.799/0.201

0.640/0.360

0.692/0.308

p = 0.549

rs11545078

16T > C

0.952/0.048

0.856/0.144

0.925/0.075

p = 1

rs12681874

14269G > A

0.638/0.362

0.533/0.467

0.890/0.110

p < 0.01

  1. *p values between our patients and Caucasian data were analyzed by Fisher’s test.
  2. SLC19A1: reduced folate carrier 1, FPGS: folylpolyglutamyl synthase, GGH: gamma-glutamyl hydrolase.
Back to article page