Figure 7
From: Osterix represses adipogenesis by negatively regulating PPARγ transcriptional activity
Working model for the regulatory effect Osterix in adipogenesis.
Osterix down-regulated expression and transcriptional activity of PPARγ in the presence of rosiglitazone by direct interaction with ligand-binding domain (LBD) of PPARγ, and ultimately repressed adipogenesis.
