Figure 1 | Scientific Reports

Figure 1

From: Specific inhibition of ICAM-1 effectively reduces bladder inflammation in a rat model of severe non-bacterial cystitis

Figure 1

Bladder inflammatory changes in rats.

HE stain, x100 magnification. (A) Normal control rats (group 1) had no edema or inflammation. (B) Cystitis model rats (group 2) had obvious inflammation, including extensive submucosa edema and marked microhemorrhage accompanied by a significantly thinner urothelium. (C) Model + celecoxib rats (group 3) had severe vascular proliferation, microhemorrhage, and errhysis with edema of the submucosa. (D) Model + aprepitant rats (group 4) showed slight congestion of the microangium and severe congestion of the submucosa. (E) Model + AIA rats (group 5) had no obvious changes except for slight edema.

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