Table 1 Bladder Inflammation Grade and Mast Cell Counts.

Bladder Inflammation Grade	Control (7)	Model (9)		Model + Clb (10)			Model + Apt (10)			Model + AIA (10)
Bladder Inflammation Grade	Control (7)	Grade	P vs Control	Grade	P vs Control	P vs Model	Grade	P vs Control	P vs Model	Grade	P vs Control	P vs Model	P vs Clb	P vs Apt
1	7	0	< 0.001	0	<0.001	0.079	0	<0.001	0.002	2	0.005	<0.001	<0.001	0.123
2	0	0		0			5			6
3	0	2		7			4			2
4	0	7		3			1			0
Mast cell	1 (0–1)	5 (3–7)	<0.001	4 (3–5)	<0.001	0.028	3 (2–4)	<0.001	0.001	2 (1–3)	0.007	<0.001	<0.001	0.019

The data are presented as the median with ranges in parentheses. The Mann-Whitney U test was used to compare nonparametric variables and pairwise differences. A value of P < 0.05 was considered a significant difference. The three intervention groups (Celecoxib, Aprepitant, and AIA) represent NBC rats that received each drug. Clb: Celecoxib; Apt: Aprepitant; AIA: Anti-ICAM-1 antibody Table 2. Cytokines and Receptors.

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