Table 2 Cytokines and Receptors.

Cytokine or Receptor	Control (7)	Model (9)		Model + Clb (10)			Model + Apt (10)			Model + AIA (10)
Cytokine or Receptor	M ± SE	M ± SE	P vs Control	M ± SE	P vs Control	P vs Model	M ± SE	P vs Control	P vs Model	M ± SE	P vs Control	P vs Model	P vs Clb	P vs Apt
P2X3 (ng/ml)	42.11 ± 7.21	280.87 ± 0.17	<0.001	182.74 ± 21.32	0.001	0.011	238.57 ± 21.27	<0.001	0.459	140.46 ± 18.09	0.003	<0.001	0.745	0.024
P2Y2 (ng/ml)	93.47 ± 0.14	354.70 ± 20.75	<0.001	169.40 ± 12.45	0.002	<0.001	188.12 ± 0.15	<0.001	<0.001	122.33 ± 14.12	0.429	<0.001	0.183	0.010
PGE2 (ng/ml)	15.06 ± 0.02	160.35 ± 19.78	<0.001	51.29 ± 4.61	<0.001	0.004	30.19 ± 0.01	<0.001	0.001	18.80 ± 0.79	0.009	0.001	<0.001	<0.001
EP1R (ng/ml)	7.30 ± 0.17	79.75 ± 9.44	<0.001	26.17 ± 2.66	0.001	0.003	16.28 ± 0.01	<0.001	0.003	11.59 ± 0.65	0.001	0.001	0.003	<0.001
EP2R (ng/ml)	5.04 ± 0.01	80.21 ± 9.99	<0.001	30.58 ± 4.87	0.005	0.007	20.04 ± 0.01	<0.001	0.006	8.54 ± 1.50	0.296	0.001	0.011	<0.001
TNF-α (ng/ml)	10.83 ± 0.16	123.14 ± 15.99	<0.001	51.30 ± 14.82	<0.001	0.040	28.53 ± 2.78	<0.001	0.003	21.82 ± 0.84	<0.001	0.002	0.046	0.292
NK1R (ng/ml)	15.42 ± 0.10	77.36 ± 7.97	<0.001	32.30 ± 1.85	0.001	0.003	32.97 ± 0.19	<0.001	0.004	21.99 ± 1.43	0.011	0.001	0.004	<0.001
ICAM-1 (pg/ml)	40.28 ± 5.76	334.18 ± 41.78	<0.001	201.37 ± 20.16	<0.001	0.118	150.38 ± 16.30	<0.001	0.017	125.06 ± 15.98	0.004	0.007	0.076	0.942

The data are presented as the means ± standard error (M ± SE). Two-way ANOVA, followed by Dunnett’s T multiple comparison test, was conducted to analyze parametric data. A value of P < 0.05 was considered a significant difference. The three intervention groups (Celecoxib, Aprepitant and AIA) represent NBC rats that received each drug. Clb: Celecoxib; Apt: Aprepitant; AIA: Anti-ICAM-1 antibody.

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