Table 2 Effects of MES + HS over time compared with baseline.

From: Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial

Adiposity

 

Baseline

MES + HS

delta

p value

Visceral Fat Area (cm2)

166.12 ± 7.75

154.44 ± 6.76

−11.69

**

SubQ Fat Area (cm2)

207.11 ± 11.95

204.04 ± 12.14

−3.07

0.205

total Fat Area (cm2)

373.23 ± 16.47

358.48 ± 16.07

−14.75

**

BMI (kg/m2)

29.14 ± 0.56

28.88 ± 0.58

−0.25

**

Wc (cm)

100.10 ± 1.33

97.86 ± 1.23

−2.24

**

Glucose control and insulin resistance

 Fasting plasma glucose (mg/dL)

159.38 ± 5.30

144.45 ± 4.21

−14.93

**

 Fasting IRI (µIU/mL)

9.77 ± 0.74

7.91 ± 0.59

−1.86

**

 HOMA-IR

4.08 ± 0.42

2.99 ± 0.29

−1.09

**

 HbA1c (%)

7.64 ± 0.08

7.28 ± 0.08

−0.36

**

 GA (%)

19.15 ± 0.41

18.40 ± 0.39

−0.75

**

 Adiponectin (µg/mL)

7.54 ± 0.47

8.47 ± 0.54

0.93

**

Blood pressure

 Systolic Blood Pressure (mmHg)

134.43 ± 1.84

132.08 ± 1.83

−2.35

*

 Diastolic Blood Pressure (mmHg)

78.38 ± 1.27

77.10 ± 1.40

−1.28

0.139

 Heart Rate (bpm)

76.85 ± 1.68

75.02 ± 1.44

−1.83

0.052

Systemic inflammation

 TNF-α (pg/mL)

1.64 ± 0.11

1.24 ± 0.08

−0.40

**

 IL-6 (pg/mL)

3.17 ± 0.29

2.78 ± 0.31

−0.44

0.105

 hs-CRP (ng/mL)

1968.77 ± 442.90

1305.17 ± 246.04

−663.60

**

 WBC (/µL)

6751.67 ± 204.86

6315.00 ± 183.01

−436.67

**

Renal function

 eGFR (mL/min/1.73 m2)

76.52 ± 2.23

79.48 ± 2.35

2.96

**

 ACR (µg/gCre)

75.20 ± 20.87

56.47 ± 15.82

−18.73

*

 L-FABP (mg/gCr)

5.42 ± 0.53

4.38 ± 0.49

−1.04

**

Hepatic steatosis and lipids

 AST/ALT

0.86 ± 0.03

0.92 ± 0.04

0.06

**

 UA (mg/dL)

5.58 ± 0.19

5.43 ± 0.18

−0.15

*

 LDL-C (mg/dL)

109.30 ± 3.54

105.80 ± 3.45

−3.50

0.055

 HDL-C (mg/dL)

52.48 ± 1.84

52.92 ± 1.65

0.43

0.354

 TG (mg/dL)

183.40 ± 18.75

153.38 ± 12.46

−30.02

*

 FFA (µEq/L)

635.62 ± 30.80

584.02 ± 25.73

−51.60

0.064

  1. p value; *<0.05, **<0.01.