Figure 1 | Scientific Reports

Figure 1

From: Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation

Figure 1

Emodin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rats.

Rats were intratracheally injected with a single dose of BLM (3.0 mg/kg) and subsequently received emodin (20 mg/kg) or vehicle by gavage daily for 21 days. (a) Representative images from different groups determined by Micro-CT showing radiologic features were presented. (b) Representative mimetic diagram drawn out from Micro-CT images, based on different tissues with varying density. (c) Lung tissue sections were prepared and stained with Masson’s trichrome staining (200x magnification). (d–f) Pulmonary function parameters including inspiratory resistance (Ri), expiratory resistance (Re) and pulmonary dynamic compliance (Cdyn) among different groups were compared three weeks after BLM instillation. Data are expressed as mean ± SD, n = 4, *P < 0.05; **P < 0.01.

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