Table 1 The in vitro antiproliferative activities of the caged compounds based on the preliminary SAR studies.

From: Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo

Compound

IC50 (μM)

HepG2

HCT116

MDA-MB-231

1

1.07 ± 0.09

1.49 ± 0.17

0.97 ± 0.09

2

1.41 ± 0.06

2.12 ± 0.14

2.00 ± 0.07

3

8.55 ± 0.43

6.10 ± 0.19

1.80 ± 0.06

4

12.70 ± 0.97

8.13 ± 0.73

5.42 ± 0.57

5

>10

>10

>10

DDO-6101

1.14 ± 0.09

0.71 ± 0.1

0.32 ± 0.09

GA

2.08 ± 0.07

0.34 ± 0.08

1.50 ± 0.05

Adriamycin

0.28 ± 0.01

0.40 ± 0.04

0.49 ± 0.05

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