Figure 1 | Scientific Reports

Figure 1

From: Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies

Figure 1

Chemical structures and key structural motifs for oligonucleotides and antibodies used in this study.

Key motifs are shown for DNA (a) and LNA (b) oligomers; (c) Binding interactions between antibody ED-10 (blue) and oligonucleotide (red). (d) Binding of two nucleotides (here dTdC from SEQ1) in binding pocket of ED-10, showing π-stacking (solid green arrows) and hydrogen bonds (dashed yellow arrows).

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