Figure 3

Comparison of the structures of TcrHGPRT and TbrHGPRT.

(A) TheTcrHGPRT.PRibPP.HPP.Mg²⁺ complex (PDB code: 1TC2) is in brown, the TcrHGPRT.IMP complex (PDB code: 1P19) is in blue, and the TbrHGPRT.GMP is in lime green. Note that the C-terminal region, including the helix, in the TcrHGPRT.IMP is disordered. (B) Interactions at the C-terminal in the TcrHGPRT.PRibPP.HPP.Mg²⁺ complex (PDB code: 1TC2). (C) Interactions at the C-terminal in the TbrHGPRT.GMP complex.