Figure 6 | Scientific Reports

Figure 6

From: Crystal structures and inhibition of Trypanosoma brucei hypoxanthine–guanine phosphoribosyltransferase

Figure 6

Stereoview of the cis to trans isomerization of the PPi binding loop in TbrHGPRT and human HGPRT.

(A) The L53-K54 peptide bond in the cis conformation in the TbrHGPRT.GMP complex (light blue) and in the trans conformation in TbrHGPRT.3 complex (magenta). (B) A comparison of the top of the PPi binding loop in TbrHGPRT (green) and human HGPRT (brown) as the L53-K54 peptide bond switches from the trans to the cis conformation.

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