Figure 5
Phosphoryation levels of lamin A and phospholamban as well as expression of their downstream genes desmin and SERCA2a significantly increased in 5/6Nx rats.
(A,C) Protein level of p-lamin A (A) and mRNA level of its downstream gene desmin (C) significantly increased in 5/6Nx + NS and 5/6Nx + HS groups. (B,D) Phosphorylation level of phospholamban decreased (B) and that resulted in decrease of mRNA level of the downstream gene SERCA2a (D) in 5/6Nx + NS and 5/6Nx + HS groups. Data are expressed as the mean ± SD of three independent experiments (n = 6 in each group). *p < 0.05 vs. Sham + NS, sham operation + normal salt; 5/6Nx + NS, 5/6Nx + normal salt; 5/6Nx + HS, 5/6Nx + high salt.
