Figure 4

In vitro cytotoxicity of DOX/SPIO-loaded micelles and DOX • HCl against BEL-7402 (A) and HepG2 cells (B). Data represent the mean ± standard deviation (n = 3). (C) BEL-7402 and HepG2 cells treated with DOX • HCl, Dex-PLGA/DOX/SPIO and A54-Dex-PLGA/DOX/SPIO micelles. Cells were stained with calcein acetoxymethyl ester (green) for visualization of live cells.