Table 2 Univariate and multivariate Cox regression analysis of prognostic factors in 246 HCC patients for overall survival.
From: High expression of GNA13 is associated with poor prognosis in hepatocellular carcinoma
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P-value | HR | 95% CI | P-value | |
Overall survival | ||||||
Age (years) | ||||||
>49 vs. ≤49 | 1.005 | 0.991–1.019 | 0.504 | |||
Sex | ||||||
male vs. female | 0.670 | 0.353–1.274 | 0.222 | |||
AFP (ng/ml) | ||||||
≥200 vs. <200 | 1.214 | 0.878–1.679 | 0.241 | |||
Liver cirrhosis | ||||||
Positive vs. Negative | 1.226 | 0.821–1.830 | 0.320 | |||
Tumor size(cm) | ||||||
>5 vs. ≤5 | 1.704 | 1.200–2.421 | 0.003* | 1.596 | 1.110–2.294 | 0.012* |
Tumor multiplicity | ||||||
Multiple vs. Single | 1.787 | 1.218–2.622 | 0.003* | 1.864 | 0.831–4.183 | 0.131 |
Pathological grade | ||||||
III-IV vs. I-II | 1.685 | 1.218–2.331 | 0.002* | 1.604 | 1.145–2.248 | 0.006* |
TNM stage | ||||||
III-IV vs. I-II | 1.583 | 1.121–2.235 | 0.009* | 0.961 | 0.580–1.593 | 0.879 |
BCLC stage | ||||||
B-C vs. 0-A | 1.736 | 1.229–2.452 | 0.002* | 0.774 | 0.324–1.852 | 0.565 |
Vascular invasion | ||||||
Positive vs. Negative | 1.887 | 1.065–3.343 | 0.029* | 2.035 | 0.849–4.881 | 0.111 |
GNA13 expression | ||||||
High vs. Low | 1.676 | 1.187–2.366 | 0.003* | 1.558 | 1.096–2.215 | 0.014* |
