Table 3 Univariate and multivariate Cox regression analysis of prognostic factors in 246 HCC patients for disease-free survival.
From: High expression of GNA13 is associated with poor prognosis in hepatocellular carcinoma
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P-value | HR | 95% CI | P-value | |
Disease-free survival | ||||||
Age (years) | ||||||
>49 vs. ≤49 | 1.002 | 0.989–1.015 | 0.782 | |||
Sex | ||||||
male vs. female | 0.669 | 0.372–1.202 | 0.178 | |||
AFP (ng/ml) | ||||||
≥200 vs. <200 | 1.200 | 0.898–1.604 | 0.217 | |||
Liver cirrhosis | ||||||
Positive vs. Negative | 1.527 | 1.051–2.219 | 0.026* | 1.747 | 1.190–2.564 | 0.004* |
Tumor size(cm) | ||||||
>5 cm vs. ≤5 cm | 1.411 | 1.040–1.915 | 0.027* | 1.379 | 1.000–1.901 | 0.050 |
Tumor multiplicity | ||||||
Multiple vs. Single | 1.956 | 1.375–2.782 | <0.001* | 1.495 | 0.619–3.612 | 0.371 |
Pathological grade | ||||||
III-IV vs. I-II | 1.489 | 1.114–1.991 | 0.007* | 1.457 | 1.079–1.969 | 0.014* |
TNM stage | ||||||
III-IV vs. I-II | 1.633 | 1.193–2.234 | 0.002* | 0.972 | 0.630–1.502 | 0.900 |
BCLC stage | ||||||
B-C vs. 0-A | 2.011 | 1.471–2.748 | <0.001* | 1.190 | 0.475–2.979 | 0.710 |
Vascular invasion | ||||||
Positive vs. Negative | 2.229 | 1.330–3.737 | 0.002* | 1.714 | 0.638–4.605 | 0.285 |
GNA13 expression | ||||||
High vs. Low | 1.654 | 1.222–2.238 | 0.001* | 1.564 | 1.148–2.132 | 0.005* |
