Figure 5
From: Multifunctional Cu2−xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
Biocompatibility analysis of the NCs and their drug release pattern intracellularly.
(a) In vitro viability analysis of cells exposed to PEGylated NCs at different concentrations (0.01–1 mg/mL) post 72 h. (b) Acidic pH dependent DOX release from PEG-NC-DOX conjugate. (c) Cellular entry analysis of PEG-NC-DOX conjugate confirmed the entry of NCs into the cell’s (MDA-MB 453) cytoplasm (DOX’s fluorescence). The images are acquired at different time points (0.5–6 h) post NC exposure. (d) In vitro cancer killing ability of PEG-NCs-DOX at different concentrations (0.01–1 mg/mL) measured with the help of alamar blue assay. MCF-7 is found to be susceptible to nano-chemotherapeutic whereas MDA MB 453 is not. Error bars indicates SE.
