Figure 2
Effects of LPS and (+)-naloxone on fetal and placental weight.
Pregnant B6 mice were administered LPS or PBS i.p. on gd 16.5, followed by (+)-naloxone or PBS i.p. on gd 16.5, 17.0, 17.5 and 18.0, then fetal weight, placental weight and fetal:placental weight ratio were measured at gd 18.5. (A) Fetal weight; (B) placental weight, and (C) fetal:placental weight ratio for surviving fetuses. Data are estimated marginal mean ± SEM, analyzed by Mixed Model Linear Repeated Measures ANOVA and post-hoc LSD t-test, with mother as the subject, adjusted for litter size. a,b,cDifferent letters indicate differences between groups, p < 0.05. *Significant effect of LPS, independent of (+)-naloxone, p < 0.05. #Significant effect of (+)-naloxone, independent of LPS, p < 0.05. Number of pregnant dams per group is shown in parentheses.
