Figure 3
From: Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model
Selected genotype-phenotype NOIA three loci models based on genotypes from the extended panel of high fat diet exposed Japanese macaques.
The Genotype (x-axis) shows the genotypes for each of the loci (ordered as PLA2G4A, APOB.1, and APOB.2) and the genotypes predicted to associate with the phenotype are outlined with colored boxes. The Genotypic Effects (y-axis) shows the NOIA predicted effect of the genotype on a phenotype. The APOB.1 locus demonstrated an additive effect on weight change percent (a), leptin/body weight ratio (b), and total fat based on DXA (c). (d) The PLA2G4A and APOB.2 loci show a combined additive effect on insulin/glucose ratio. (e) The PLA2G4A locus shows an additive effect on triglyceride levels. (f) The APOB.2 locus shows an additive effect on free fatty acid levels.
