Figure 6 | Scientific Reports

Figure 6

From: A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis

Figure 6

Alterations of genes and miRNAs in GK rats.

Blood glucose levels in Wistar rats (white bar, control) and GK rats (black bar) (A). mRNA (B) and protein (C) levels of genes specific for beta cells. miR-375, miR-30a and miR-34a expression levels (D). mRNA (E) and protein (F) levels of NOTCH1 and components of γ-secretase. Data shown are means ± SEM. *p < 0.05 or **p < 0.01 vs. control. n = 6 per group.

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