Figure 4 | Scientific Reports

Figure 4

From: CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells

Figure 4

Temporal histological analysis showing the late onset of the phenotype.

(a) Sequential analysis of the distal femur shows normal bone development in experimental mice up to 4 weeks of postnatal life while wide areas of cortical bone loss (arrows) are observed in 12-week-old experimental animals. (b) Pictures of fresh dissected distal femur showing the dramatic bone loss of experimental animals. (c) The sequential analysis of lumbar vertebrae shows normal bone development in experimental mice up to 4 weeks with a dramatic bone loss phenotype observed in 12-week-old experimental animals. (d) Detail of the bone marrow of the 12-week-old femurs in (A) showing the extensive adiposity characteristic of experimental animals. (e) Hematoxylin-eosin stained histological sections of the proximal humerus of control and experimental. Scale bar, 1000 μm.

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