Figure 2 | Scientific Reports

Figure 2

From: NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase

Figure 2

NPNT gene expression was down-regulated in OVX mice and in osteoporotic patients.

(A) Tibias from sham group (left) and OVX group (right) were visualized by μCT scanning, and the ROI focused on the trabecular region below the growth plate for quantitative analysis of (B) Tb.BV/TV, (C) Tb.Th, (D) Tb.N and (E) Tb.Sp. Real-time PCR quantitative analysis of (F) Runx2, (G) OCN and (H) NPNT gene expression in mouse forelimbs. n = 6/group. (I) μCT images of trabecular bone in the region between head and neck of femur from patients with osteoarthritis (top) and osteoporosis (bottom), and quantitative analysis of (J) Tb.BV/TV, (K) Tb.Th, (L) Tb.N and (M) Tb.Sp. Real-time PCR quantitative analysis of (N) Runx2, (O) OCN and (P) NPNT gene expression in human femora. n = 20/group. The gene expressions were normalized to β-Actin and 18S. *P < 0.05.

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