Figure 3
From: Large-scale identification of adverse drug reaction-related proteins through a random walk model
Method evaluation.
(a) ROC curve of the INPADR and enrichment analysis method. The INPADR and enrichment analysis method are compared in terms of ROC curve and AUC using leave-one-out cross validation of 503 known protein-ADR relations. (b) ROC curve of the INPADR and the RWR. In the process of leave-one-out cross validation, the RWR only on the protein interaction network just is evaluated on the ADRs related with at least two proteins. Here, 398 known ADR-protein relations for ADRs related with at least two proteins are considered as the gold-standard set.
