Table 3 The adjusted hazards ratio of risk factors of local recurrence in patients with primary GCTB around the knee.

From: Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China

Risk factors

Reference

Univariate Analysis

Multivariate Analysis

Unadjusted HR (95% CI)

P

Adjusted HR (95% CI)

P

Men

Women

0.82 (0.51, 1.31)

0.404

  

Age

0.98 (0.96, 1.00)

0.068

  

Left Knee

Right Knee

0.79 (0.50, 1.26)

0.329

  

Location

Distal femur

    

 Proximal tibia

 

1.06 (0.66, 1.70)

0.817

0.81 (0.50, 1.32)

0.400

 Proximal fibular

 

21.54 (4.89, 94.78)

<0.0001

28.52 (5.88, 138.39)

<0.0001

Campanacci grade

I

    

 II

 

0.59 (0.26, 1.30)

0.187

  

 III

 

0.55 (0.26, 1.19)

0.130

  

Pathologic fracture

No

0.66 (0.41, 1.07)

0.092

  

Surgical approach

En bloc marginal resection

    

 Intralesional curettage

 

11.25 (4.69, 26.97)

<0.0001

12.07 (4.99, 29.18)

<0.0001

 Curettage combined with resection

 

5.85 (2.45, 13.96)

<0.0001

6.39 (2.66, 15.36)

<0.0001

PMMA

No

1.16 (0.75, 1.77)

0.516

  
  1. PMMA indicated polymethylmethacrylate.