Figure 2 | Scientific Reports

Figure 2

From: Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE−/− mice: implications for Alzheimer’s disease

Figure 2

The clock gene expression in the ApoE−/− and C57BL/6J SCN.

(a–c) The circadian pattern of PER1, PER2 and BMAL1 mRNA of the SCN lysate prepared from ApoE−/− and C57BL/6J mice. Note that the transcript peaks of the three genes all phase-advanced in the ApoE−/− mice (n = 5 for each gene at each time point in each strain). (d) Scatter dot plot and mean ± SD for the transcript levels of PER1, PER2 and BMAL1 in the SCN of both strains examined at CT12. Note that the greater variability in the transcript levels in the ApoE−/− mice than C57BL/6J mice (n = 5 for both ApoE−/− and C57BL/6J mice).

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