Figure 3 | Scientific Reports

Figure 3

From: Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE−/− mice: implications for Alzheimer’s disease

Figure 3

Neurodegenerative pathologies of ApoE−/− mice.

(a,b) Immunohistochemical staining of Aβ and tau in the SCN, hippocampus and retina of ApoE−/− and C57BL/6J mice. The upper right large inlets in the SCN panel shows the enlarged images of the framed areas indicated by the small square. (c) Immunohistochemical staining of melanopsin (brown color) in the RGC layer (arrow) in the retina of the ApoE−/− and C57BL/6J mice, together with image quantitation result (n = 6 for both ApoE−/− and C57BL/6J mice, ** indicates P < 0.01).

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