Figure 5 | Scientific Reports

Figure 5

From: Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE−/− mice: implications for Alzheimer’s disease

Figure 5

The altered SIRT1-mediated energy metabolism in ApoE−/− SCN.

(a) The circadian pattern of NAD+/NADH ratio of the SCN lysates prepared from the ApoE−/− and C57BL/6J mice. (b) The circadian pattern of SIRT1 mRNA of the SCN lysate prepared from the ApoE−/− and C57BL/6J mice. (c) The representative Western blots for SIRT1 protein of the SCN lysate prepared from the ApoE−/− and C57BL/6J mice, together with the quantitative scanning densitometry result (d) (n = 6 for each gene at each time for both ApoE−/− and C57BL/6J mice, **indicates P < 0.01). β-actin was used as a loading control. Cropped images were used and the full-length blots were presented in Supplementary Fig. 4.

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