Figure 8 | Scientific Reports

Figure 8

From: Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE−/− mice: implications for Alzheimer’s disease

Figure 8

Intraperitoneal administration of nicotinamide partially reversed abnormal locomotor rhythmicity of ApoE−/− mice.

(a) Representative actograph showing the wheel-running activities of ApoE−/− mice intraperitoneally injected with nicotinamide or saline at the CT22 in each day consecutively for 10 days under the DD condition (the administration at each day indicated by *). Note that the fragmented activity-onsets became well aligned during administration and lasted for 3 days after nicotinamide withdrawal. (b,c) Locomotor activity in the subjective day and night phases and day/night activity ratio under the DD condition of ApoE−/− mice injected with nicotinamide. (d) The circadian expression of SIRT1 mRNA expression in ApoE−/− SCN after nicotinamide administration. Note that the 8-hour phase advance was reversed (n = 5 at each time point for both ApoE−/− and C57BL/6J mice, **indicates P < 0.01).

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