Figure 4

Potential biomarkers for postmenopausal osteoporosis and mechanical unloading induced osteoporosis.

(a) miR-30b-5p was validated to be down-regulated in the serum of both osteopenic (n = 7) and osteoporotic (n = 10) patients compared with the normal BMD subjects (n = 19), miR-103-3p, miR-142-3p and miR-328-3p were validated to be down-regulation in the osteoporotic patients. *p < 0.05, **p < 0.01. (b) The potential diagnostic value of miR-30b-5p for bone loss (both osteopenia and osteoporosis), and miR-103-3p, miR-142-3p, miR-328-3p for osteoporosis was evaluated by ROC analysis. (c) Three miRNAs (miR-30b-5p, miR-103-3p, miR-142-3p) were validated to be down-regulated in the serum of rhesus monkeys with 42 days’ bedrest (n = 6) compared with the control group (n = 9). *p < 0.05. (d) The potential diagnostic value evaluated by a ROC analysis. AUC = area under the curve, CI = confidence interval.