Table 1 Body weight, food intake and serum parameters in PyMT and PyMT-hApoA-I mice.

From: ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer

 

PyMT

PyMT-hApoA-I

p

Body weight (g)

22.95 ± 0.55

23.67 ± 0.58

0.38

Food intake (g/day)

3.41 ± 0.33

3.80 ± 0.16

0.29

Total serum cholesterol (mmol/L)

2.05 ± 0.10

3.72 ± 0.21

<0.0001

HDL cholesterol (mmol/L)

1.80 ± 0.14

3.56 ± 0.25

<0.0001

HDL mass (g/L)

3.08 ± 0.20

8.12 ± 0.34

<0.001

hApoA-I (g/L)

ND

2.99 ± 0.17

 

mApoA-I (g/L)

1.04 ± 0.10

0.66 ± 0.09

<0.05

pre-β HDL levels (% of mApoA-I)

0.51 ± 0.51

1.78 ± 0.81

0.21

  1. Values represent the mean ± SEM for 8–10 mice/group. ND, non-detected; hApoA-I, human apoA-I; mApoA-I, mouse apoA-I. Statistical significance was considered when p ≤ 0.05 vs. the PyMT group.
Back to article page