Table 2 Odds ratios of SUA and TBIL for CVD in type 2 diabetes.

From: Interactive effect of serum uric acid and total bilirubin for cardiovascular disease in Chinese patients with type 2 diabetes

Exposures

N (%) of CVD‡

OR (95% CI)

P value

All patients

 Model 1*: SUA ≥283 umol/l vs. <283 umol/l

330 (9.82):231 (6.89)

1.47 (1.23,1.75)

<0.0001

 Model 2†: SUA ≥283 umol/l vs. <283 umol/l

330 (9.82):231 (6.89)

1.49 (1.25,1.78)

<0.0001

 Model 1*: TBIL < 11.5 umol/l vs. ≥11.5 umol/l

271 (6.13):290 (12.66)

2.22 (1.86,2.64)

<0.0001

 Model 2†: TBIL < 11.5 umol/l vs. ≥11.5 umol/l

271 (6.13):290 (12.66)

2.15 (1.80,2.56)

<0.0001

 Model 3*: TBIL ≥ 11.5 umol/l vs. <11.5 umol/l

290 (12.66):271 (6.13)

0.45 (0.37,0.53)

<0.0001

 Model 4†: TBIL ≥ 11.5 umol/l vs. <11.5 umol/l

290 (12.66):271 (6.13)

0.46 (0.39,0.55)

<0.0001

Among patients with TBIL ≥ 11.5 umol/l

 Model 1*: SUA ≥283 umol/l vs. <283 umol/l

156 (5.69):115 (6.83)

0.82 (0.64,1.05)

0.1254

 Model 2†: SUA ≥283 umol/l vs. <283 umol/l

156 (5.69):115 (6.83

0.80 (0.62,1.04)

0.0984

Among patients with TBIL < 11.5 umol/l

 Model 1*: SUA ≥283 umol/l vs. <283 umol/l

174 (28.02):116 (6.95)

5.21 (4.02,6.81)

<0.0001

 Model 2†: SUA ≥283 umol/l vs. <283 umol/l

174 (28.02):116 (6.95)

5.25 (4.06,6.81)

<0.0001

Among patients with SUA < 283 umol/l

 Model 1*: TBIL < 11.5 umol/l vs. ≥11.5 umol/l

116 (6.95):115 (6.83)

1.01 (0.78,1.33)

0.8934

 Model 2†: TBIL < 11.5 umol/l vs. ≥11.5 umol/l

116 (6.95):115 (6.83)

0.97 (0.74,1.27)

0.8602

 Model 3*: TBIL ≥ 11.5 umol/l vs.<11.5 umol/l

115 (6.83):116 (6.95)

0.98 (0.75,1.28)

0.8934

 Model 4†: TBIL ≥ 11.5 umol/l vs. <11.5 umol/l

115 (6.83):116 (6.95)

1.02 (0.78,1.34)

0.8602

Among patients with SUA ≥ 283 umol/l

 Model 1*: TBIL < 11.5 umol/l vs. ≥11.5 umol/l

174 (28.02):156 (5.96)

6.44 (5.08,8.18)

<0.0001

 Model 2†: TBIL < 11.5 umol/l vs. ≥11.5 umol/l

174 (28.02):156 (5.96)

6.45 (5.06,8.23)

<0.0001

 Model 3*: TBIL≥11.5 umol/l vs. <11.5 umol/l

156 (5.96):174 (28.02)

0.15 (0.12,0.19)

<0.0001

 Model 4†: TBIL ≥ 11.5 umol/l vs. <11.5 umol/l

156 (5.96):174 (28.02)

0.15 (0.12,0.19)

<0.0001

  1. SUA, serum uric acid; TBIL, total bilirubin; CVD, cardiovascular disease; N (%), number of cases (% of number at risk); OR, odds ratios; CI, confidence interval.
  2. *Univariable model, not adjusted for any other variables.
  3. †Multivariable model, age, duration of diabetes, gender, body mass index, systolic blood pressure, diastolic blood pressure, glycated hemoglobin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, self-monitoring, log-transformed urinary albumin to creatinine ratio, and drug use and complications as listed in Table 1,were adjusted in multivariable analysis (Valid sample size = 6707, with 6 missing ACR).
  4. ‡N (%), number of cases (% of number at risk).
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