Table 4 Measures of additive interaction between SUA and TBIL for the risk of CVD.

From: Interactive effect of serum uric acid and total bilirubin for cardiovascular disease in Chinese patients with type 2 diabetes

Measures of interaction

Estimated value

95%CI

P value

Univariable model

 RERI

4.46

3.30–5.62

<0.001

 AP

0.84

0.77–0.90

<0.001

 S

−27.19

NA

NA

Multivariable model

 RERI

4.40

3.25–5.54

<0.001

 AP

0.84

0.77–0.90

<0.001

 S

−19.46

NA

NA

  1. SUA, serum uric acid; TBIL, total bilirubin; CVD, cardiovascular disease ; CI, confidence interval; RERI, relative excess risk of interaction; AP, attributable proportion; S, synergy index; NA, not available.
  2. Univariable model: not adjusted for any other variables.
  3. Multivariable model: age, duration of diabetes, gender, body mass index, systolic blood pressure, diastolic blood pressure, glycated hemoglobin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, self-monitoring, log-transformed urinary albumin to creatinine ratio, and drug use and complications as listed in Table 1 were adjusted in multivariable analysis (Valid sample size = 6707, with 6 missing ACR).
Back to article page