Figure 1
From: The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells
PrP and Sho constructs used in the studies.
Schemes of the polypeptide chains indicate the domain structures and features of interest. αA, αB, αC: alpha helices. Narrow, tall, dark green boxes: β-strands. CHO: N-glycosylation sites. GPI: GPI-anchors. Blue brackets: disulphide bonds. Striated boxes: polybasic regions (PB1 (blue), PB2 (white) in PrP, (RXXX)8 in Sho), whereas, the non-striated blue boxes in Sho(QXXX)8 construct indicate the (QXXX)8 region. Red boxes in PrP: octarepeat region (OR). Yellow and orange boxes: hydrophobic domains (HD) of PrP or Shadoo, respectively. Numbers indicate the last and first residues neighbouring the deletions. Green tones: structured region of PrP.
