Table 2 The distribution of mannose-binding lectin (MBL) genotypes and haplotype pairs associated with various levels of MBL expression in patients with tuberculosis and control subjects.

From: Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese

Polymorphisms

No. of casesa (n = 1,020)

No. of controlsa (n = 1,020)

OR (95% CI)b

P b

OR (95% CI)c

P c

H/L

276/498/246

231/532/257

1.06 (0.86–1.29)

0.60

1.07 (0.90–1.27)

0.53

Y/X

27/214/779

25/246/749

0.86 (0.71–1.06)

0.14

0.85 (0.72–1.01)

0.13

P/Q

12/210/798

11/248/761

0.83 (0.67–1.01)

0.065

0.82 (0.69–0.98)

0.062

A/B

30/345/645

14/258/748

1.57 (1.30–1.91)

1.3 × 10−6

1.59 (1.36–1.87)

2.2 × 10−6

Expression groups

104/298/618

63/234/723

1.56 (1.29–1.90)

1.4 × 10−6

1.59 (1.35–1.86)

1.8 × 10−6

  1. OR, odds ratio; CI, confidence interval.
  2. H/L, Y/X, and P/Q are functional promoter polymorphisms at nt −550, −221, and +4, respectively. A is wild-type codon 54 and B is the codon 54 variant.
  3. Expression groups include haplotype pairs associated with high- or medium- and low- MBL expression. High-MBL expression haplotype pairs are HYA/HYA, HYA/LYA, HYA/LXA, LYA/LYA, and LYA/LXA; medium-MBL expression haplotype pairs are LXA/LXA, HYA/LYB, and LYA/LYB; and low-MBL expression haplotype pairs are LXA/LYB and LYB/LYB.
  4. The P values and ORs (95% CI) are for the comparison between the homozygous wild-type genotype and the homozygous and heterozygous variant genotypes, for each polymorphism, and for the comparison of the haplotype pairs associated with high-MBL expression with those associated with medium- and low- MBL expression.
  5. aNumber of LL genotype/HL genotype/HH genotype in H/L locus, XX genotype/YX genotype/YY genotype in Y/X locus, QQ genotype/PQ genotype/PP genotype in P/Q locus, BB genotype/AB genotype/AA genotype in A/B locus, and low-MBL expression haplotype pairs/medium- MBL expression haplotype pairs/high-MBL expression haplotype pairs.
  6. bThe P values, ORs, and 95% CI are calculated in logistic regression with age and gender treated as fixed effects.
  7. cThe P values, ORs, and 95% CI are calculated in logistic regression with age and gender treated as random effects.
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