Table 3 Haplotypes for the four SNPs in MBL2 gene and their associations with TB risk in Chinese.

From: Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese

Haplotypes

Cases, 2n (%) n = 2,040

Controls, 2n (%) n = 2,040

Scorea

P valuea

OR (95% CI)b

HYPA

990 (48.5)

1046 (51.3)

−2.36

0.018

1

LYPB

405 (19.9)

286 (14.0)

4.69

4.2 × 10−6

1.54 (1.27–1.87)

LXPA

268 (13.1)

296 (14.5)

−1.33

0.18

0.89 (0.72–1.10)

LYQA

234 (11.5)

270 (13.2)

−1.71

0.087

0.88 (0.70–1.09)

LYPA

143 (7.0)

142 (7.0)

0.020

0.98

1.04 (0.80–1.35)

  1. OR, odds ratio; CI, confidence interval. The haplotype is in the order of H/L, Y/X, P/Q and A/B.
  2. aHaplotype-specific scores and P values for each haplotype versus all others and the P value for global haplotype association are evaluated using the haplo.score-function. The global P value is 3.5 × 10−5.
  3. bThe ORs (95% CI) are calculated for haplotypes LYPB, LXPA, LYQA and LYPA using the haplo.glm-function, with haplotype HYPA as control.
Back to article page