Figure 4
QA injections enhance functional connectivity (FC) between different cortical areas of the mouse brain.
(a) Seed-based analysis of the right prefrontal cortex, FC matrices and FC strength in 3 slices of the statistical difference map between sham (n = 10) and QA-injected mice (n = 12; p < 0.001, uncorrected, voxel threshold of 10 voxels; lesion >sham). The color scale on the right indicates the T value (i.e., the magnitude of the difference between both conditions). The regions that showed higher FC in the QA-injected group are indicated on corresponding slices of the Franklin and Paxinos anatomical mouse brain atlas with (1) prefrontal cortex, (2) motor cortex, (3) cingulate/retrosplenial cortex, (4) somatosensory cortex and (5) CA1 region of hippocampus. Black spot on first brain slice on the left indicates the lesion site. (b) The panel on the left side shows mean zFC matrix of the sham (below the diagonal) and QA-injected group (above the diagonal). The panel on the right side shows a graph with mean FC ± standard error for each brain region in sham and lesion groups. **p < 0.01. The color scale represents the strength of the functional correlation between pairs of brain regions. Abbreviations: CA1 = CA1 region of the hippocampus, Cg = cingulate cortex, PFC = prefrontal cortex, MC = motor cortex, Resp = retrosplenial cortex, SS = somatosensory cortex.
