Figure 4 | Scientific Reports

Figure 4

From: Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer

Figure 4

DR5 and IAPs gene expression in KRAS-mutant (KRAS-G13D, KRAS-G12D, KRAS-G12V) and KRAS wild-type CRC tissues.

(A) Box plots show the significant over-expression of DR5 in CRCs regardless of KRAS mutation status, (B) Box plots show significant down-regulation of cIAP1 in CRC tissues regardless of KRAS mutation status, (C) Box plots show the significant over-expression of BIRC5/Survivin in KRAS wild-type CRC tissues, but not in KRAS-mutant ones, (D) Box plots show significant down-regulation of cIAP2 in KRAS-mutant CRC tissues, but not in KRAS wild-type ones, (E,F) Box plots show that the deregulation of XIAP and DR4 mRNA expression in CRC is not significant in KRAS mutation status sybgroups of patients.

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