Table 3 Protein expression of DR4, DR5, BIRC5/Survivin, cIAP1 and cIAP2 by immunohistochemistry.

From: Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer

Tumor samples

PROTEIN EXPRESSION OF DR4, DR5, cIAP1, cIAP2 and BIRC5/Survivin BY IMMUNOHISTOCHEMISTRY

DR4

DR5

cIAP1

cIAP2

BIRC5/Survivin

KRAS mutation status

Differentiation

TNM

T24

+++

+++

+

+

++

KRAS mutant

Middle-low

T3N2M1

T108

+++

++

+

+

++

KRAS mutant

N/A

T3N0M0

T113

++

++

+

+

+++

KRAS wild type

Middle

T2N1M0

T114

+

+

+

KRAS mutant

N/A

N/A

T118

++

+

+

+

KRAS wild type

Middle

T3N2M0

T121

++

+

+

KRAS mutant

N/A

N/A

T127

++

+

+

+

++

KRAS mutant

Middle

T1N1M0

T131

++/+++

++/+++

+

+

++

KRAS wild type

Middle

T2N1M0

T132

+++

++

+

+

++

KRAS mutant

Middle

T2N1M1

T139

+++

+++

+

+

++

KRAS wild type

Middle

T3N0M0

T140

+

+/++

+/−

KRAS mutant

N/A

N/A

T145

+++

++

+

+

++

KRAS mutant

Middle

T3N1M0

T151

+++

+++

+

+

+++

KRAS mutant

Middle

T3N1M0

T166

+++

++

+/−

++

KRAS wild type

Low

T2N0M0

T167

+++

+++

+

+

++

KRAS wild type

Middle

T3N1M1

T178

+++

+++

+

+

++

KRAS wild type

Middle

T3N1M0

T182

+++

++

+

+

++

KRAS wild type

Low

T3N0M0

T185

++

++

+

++

KRAS mutant

Middle

T3N2M1

T189

+++

+++

+/−

+

+++

KRAS mutant

Low

T3N1M0

T193

+++

+++

+

+

++

KRAS mutant

Middle

T3N2M0

T194

++

+

+/−

+

+

KRAS mutant

Middle

T3N0M0

T196

+++

+++

+

+

+++

KRAS mutant

Middle

T3N1M0

T197

+++

++

+

+++

KRAS mutant

Low

T3N0M0

T200

++

++

+

+

KRAS mutant

Middle

T3N0M0

T201

++

+

+/−

+

+

KRAS mutant

Middle

T3N2M1

  1. T: tumor; +: mild reactivity; ++: moderate reactivity; +++: strong reactivity; −: negative reactivity; N/A: information not available.