Table 1 atient characteristics and clinicopathological variables, and their prognostic value for the biochemical and clinical failure in 535 prostate cancer patients (univariate analyses; log rank test).

From: Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study

Characteristic

Patients (n)

Patients (%)

BF (200 events)

CF (56 events)

5-year EFS (%)

p

10-year EFS (%)

p

Age

   

0.237

 

0.038

 ≤ 65 years

357

67

77

 

94

 

 >65 years

178

33

70

 

91

 

pT-stage

   

<0.001

 

<0.001

 pT2

374

70

83

 

97

 

 pT3a

114

21

61

 

87

 

 pT3b

47

9

43

 

74

 

Preop PSA

   

<0.001

 

0.029

 PSA < 10

308

57

81

 

95

 

 PSA > 10

221

42

68

 

89

 

 Missing

6

1

 

 

Gleason

   

<0.001

 

<0.001

 3 + 3

183

34

83

 

98

 

 3 + 4

219

41

77

 

94

 

 4 + 3

81

15

70

 

90

 

 4 + 4

17

4

58

 

86

 

 ≥9

35

6

37

 

65

 

Tumor Size

   

<0.001

 

0.002

 0–20 mm

250

47

83

 

96

 

 >20 mm

285

53

68

 

90

 

PNI

   

<0.001

 

<0.001

 No

401

75

80

 

96

 

 Yes

134

25

60

 

83

 

PSM

   

0.049

 

0.198

 No

249

47

81

 

96

 

 Yes

286

53

69

 

90

 

Non-apical PSM

   

<0.001

 

<0.001

 No

381

71

82

 

96

 

 Yes

154

29

57

 

85

 

Apical PSM

   

0.063

 

0.427

 No

325

61

74

 

92

 

 Yes

210

39

77

 

93

 

LVI

   

<0.001

 

<0.001

 No

492

92

77

 

95

 

 Yes

43

8

47

 

69

 

Surgical proc

   

0.466

 

0.308

 Retropubic

435

81

77

 

92

 

 Perineal

100

19

68

 

95

 

Tumor cell miR-210

   

0.85

 

0.09

 High expression

162

30

73

 

91

 

 Low expression

183

34

73

 

94

 

 Missing

190

36

    

Fibroblast miR-210

   

0.23

 

0.001

 High expression

310

58

74

 

90

 

 Low expression

187

35

79

 

97

 

 Missing

38

7

    
  1. Abbreviations: BF = biochemical failure; CF = Clinical failure; EFS = event free survival in months; LVI = lymphovascular infiltration, PCD = prostate cancer death; NR= not reached; P = P value for log rank statistic for difference in event free survival; PC = Prostate cancer; PNI = Perineural infiltration; Post op RT = postoperative radiotherapy; Preop = preoperative; PSA=Prostate specific antigen; PSM = Positive surgical margin; Surgical proc = surgical procedure;