Table 1 Initial conditions and parameters for numerical simulations of apoptosis induction in mitotic arrest.
Initial conditions/parameter values | Value | Units | Description |
|---|---|---|---|
[B1], [B2], [B4], [B8], [B16], [B32], [B64], [B128], [B256] | 0.0 | nM | Bak oligomeric species |
[M] | 3000.0 | nM | Free Mcl-1 |
[MB] | 1000.0 | nM | Mcl-1/Bak complex |
[Cm] | 1000.0 | nM | Mitochondrial CytC |
[Cc] | 0.0 | nM | Cytoplasmic CytC |
σ M | 5 × 10−6 | nM/s | Mcl-1 synthesis rate in mitosis |
δ M | 1.3 × 10−4 | 1/s | Mcl-1 degradation rate in mitosis |
α M | 0.05 | 1/nM/s | Bak/Mcl-1 association rate |
β M | 0.5 | 1/s | Bak/Mcl-1 dissociation rate |
γ m | 5000.0 (Model I) 0.5 (Model II) | 1/nM/s | CytC cytoplasmic translocation rate |
γ C | 0.5 | 1/s | CytC mitochondrial translocation rate |
α 1→2 | 0.05 | 1/nM/s | Bak dimerization rate |
β 1→2 | 500.0 | 1/s | Bak dimer dissociation rate |
α 2→4 | 0.05 | 1/nM/s | Bak tetramer association rate |
β 2→4 | 0.05 | 1/s | Bak tetramer disassociation rate |
α i→j | 1 | 1/nM/s | Association rates of all other oligomers |
β i→j | 1 | 1/s | Dissociation rates of all other oligomers |
