Figure 2

Impact of IFX and DEX on CDE diet mediated liver injury parameters and CK19⁺ cell distribution.

(A) Experimental design: IFX was injected i.p daily from day 7 of CDE treatment whereas DEX was injected from day 9 onwards in a 14 day time course. (B) Quantification of ALT, ALP, and total-bilirubin in sera and hydroxyproline levels in livers from DDC-treated mice +/− DEX or IFX. (C) Representative pictures of immunohistochemistry for CK19 on CDE-treated livers with or without DEX or IFX are shown. The dotted windows in the left panels are magnified and presented in the middle panels. Higher magnifications of CK19⁺ cells are given in the two right panels. All images were taken in 20x original magnification.All data are mean (+/−SEM) for n = 5/group. *p < 0.05, **p < 0.01, and ***p < 0.001 difference versus CTL. ^#p < 0.05 and ^##p < 0.01 difference versus treated groups (CDE). ^£p < 0.05 and ^££p < 0.01 difference versus co-treated groups (+/−DEX or +/−IFX).