Figure 7
From: Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice
DEX and IFX influence the proliferative status of the DR in CDE- and DDC-treated livers.
(A) Mice received CDE or DDC dietary regimes for 14 days to induce liver injury. Representative pictures of the detection of CK19/Ki-67 double positive cells in presence or absence of DEX or IFX are shown and (B) Quantification of the amount of Ki-67 positive cells per hepatic cell type per field: hepatocytes (HEP, Albumin+), HSC (Desmin+); LSEC (Lyve1+), KC (F4/80+), BEC (CK19+). Right graph: representation of only Ki-67/CK19 double positive cells per field. PV = portal vein. All data are mean for n = 5/group. ***p < 0.001 difference versus CTL. ###p < 0.001 difference versus treated groups (DDC or CDE). £££p < 0.001 difference versus co-treated groups (+/−DEX or +/−IFX). All images were taken at 20x original magnification.
