Table 2 Retargeted FVs integrate within satellite repeat elements.

From: Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes

Vector

Total sites

Percent of RIS

Centromerea

In repeat elements

LINE

SINE

Satellite

DNA

LTR

ControlIMR90

2306

3.9

20.9

20.7

2.4

2.6

7.3

IN-CBX1IMR90

3994

4.7**

16.5***

18.4***

3.1**

2.8

8.6**

Gag-RTYIMR90

3382

37.0***

16.0***

13.1***

36.2***

1.5***

4.8***

IN-CBX1 & Gag-RTYIMR90

2224

37.1***

18.8*,###

15.7***,###

36.2***

1.1***

4.1***

ControlCD34

5351

1.3

16.8

22.7

1.0

2.3

7.5

IN-CBX1 & Gag-RTYCD34

3175

26.8***

16.5

18.3***

31.1***

1.4***

5.7***

Random

10000

3.5

21.0

12.8

0.4

3.5

9.6

  1. **Statistically significant at p < 0.01 compared to control vector.
  2. ***Statistically significant at p < 0.001 compared to control vector.
  3. ###Statistically significant at p < 0.001 compared to Gag-RTY vector.
  4. aLess than 1 Mbp from centromere. RIS, retroviral vector integration sites.
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