Figure 4
From: Distinct role of IL-1β in instigating disease in Sharpincpdm mice
IL-1R deficiency in Sharpincpdm mice delays the development of skin disease.
(a) Control (n = 9), Sharpincpdm (n = 7), and Sharpincpdm × Il1r−⁄− (n = 7) mice were followed after weaning and scored for the onset of dermatitis. Mice that showed any sign of skin inflammation were scored as disease-positive and indicated in the disease score curves on that day. (b) Representative images of control and Sharpincpdm mice on day 45 and Sharpincpdm × Il1r−⁄− mice on day 70 post birth, depicting the extent of dermatitis on the dorsal and ventral sides. White dotted line outlines the area of dermatitis in Sharpincpdm mice. The disease curve in (a) was analyzed by log rank (Mantel-Cox) testing. ***P < 0.001.
