Figure 2 | Scientific Reports

Figure 2

From: Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues

Figure 2

Cisplatin effects and distribution in the small intestine.

(a) Representative total ion current images, Pan-Keratin, IdU, DNA, E-cadherin, γH2AX, and αSMA, Collagen I, 195Pt, and Histone H3 images of small intestine from control and cisplatin-treated (4 mg/kg for 24 h) OCIP28 PDX mice. Scale bar = 100 μm. (b) Percentage of positive IdU bar graph (left) and platinum distribution in collagen and non-collagen epithelial tissue area of small intestine. (c) Representative IdU, 195Pt, and Histone H3 images of control, cisplatin-treated (4 mg/kg for 24 h and 48 h) small intestine. Scale bar = 100 μm.

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