Figure 2

Graphs of fold induction (as luciferase activity) from assays in the MN8CampLuc reporter cell line (pre-differentiated) with the novel class of inducers represented by compounds 2–9 and also compared with induction by 2 mM PBA.

The fold induction values are relative to the background from untreated cells (as indicated by the horizontal red line) and all experiments were performed in duplicate. Experiments presented in (a,b) respectively, were performed at different occasions. Bars for standard deviation are shown and all differences relative to untreated cells were statistically significant (Student’s t-test p-values were all < 0.01 except for 2.5 μM of 2 (in (a) p-value, 0.024)). Differences relative to 2 mM PBA (1) were significant for all compounds and concentrations except for the lowest concentration (2.5 μM) of 8 and 9 (in (b) p-values were 0.14 and 0.25 respectively). All other Student’s t-test p-values were < 0.01 except for 10 μM concentration of 6 (in (a) p-value 0.033).