Figure 2 | Scientific Reports

Figure 2

From: Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer

Figure 2

Differential treatment effects on primary breast tumor blood vessels.

Orthotopic primary LM2-4 breast tumors harvested after 2 weeks of therapy were analyzed for tumor vascularity by CD31 staining. (A) Automated quantification of CD31-positive pixels normalized to total pixels at 100×, with mean ± SEM depicted. Predefined comparisons (control vs. monotherapies; paclitaxel monotherapy vs. paclitaxel-containing combinations) were subjected to two-sampled unpaired t tests (n = 5 to 11 mice per group). (B) Representative microscopy images of CD31-stained breast tumor sections.

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